(A) Representation of the visual field seen by an individual with normal vision and by an AMD patient with a loss of central color vision. (B) Schematic of a normal human eye compared with a wet AMD eye, depicting choroidal neovascularization with subretinal hemorrhage in the macula (red). (C) Schematic cross-section of a normal eye through the macula showing retinal neuronal layers, retinal pigment epithelium, Bruch membrane, and choroid vessels. In wet AMD, with choroidal neovascularization, abnormal leaky choroidal vessels proliferate and penetrate the altered Bruch membrane protruding into the subretinal space, causing hemorrhage and rapid loss of vision. Figure adapted from ref. 20.