[HTML][HTML] Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
JB Wardenburg, C Fu, JK Jackman, H Flotow… - Journal of Biological …, 1996 - ASBMB
Two families of tyrosine kinases, the Src and Syk families, are required for T-cell receptor
activation. While the Src kinases are responsible for phosphorylation of receptor-encoded
signaling motifs and for up-regulation of ZAP-70 activity, the downstream substrates of ZAP-
70 are unknown. Evidence is presented herein that the Src homology 2 (SH2) domain-
containing leukocyte protein of 76 kDa (SLP-76) is a substrate of ZAP-70. Phosphorylation of
SLP-76 is diminished in T cells that express a catalytically inactive ZAP-70. Moreover, SLP …
activation. While the Src kinases are responsible for phosphorylation of receptor-encoded
signaling motifs and for up-regulation of ZAP-70 activity, the downstream substrates of ZAP-
70 are unknown. Evidence is presented herein that the Src homology 2 (SH2) domain-
containing leukocyte protein of 76 kDa (SLP-76) is a substrate of ZAP-70. Phosphorylation of
SLP-76 is diminished in T cells that express a catalytically inactive ZAP-70. Moreover, SLP …
