[CITATION][C] NF-κ B and chemoresistance: Potentiation of cancer drugs via inhibition of NF-κ B
JC Cusack, R Liu, AS Baldwin - Drug Resistance Updates, 1999 - Elsevier
1Lineberger Comprehensive Cancer Center, 2Department of Surgery, University of North
Carolina School of Medicine, NC, USA he transcription factor NF-κB is an intensively studied
regulator of gene expression involved in immune and inflammatory responses. In most cells,
the bulk of NF-κB is found in the cytoplasm associated with an inhibitor known as IκB. In
response to a variety of stimuli, including the proinflammatory cytokine TNFα, IκB becomes
phosphorylated which leads to its ubiquitination and subsequent degradation by the …
Carolina School of Medicine, NC, USA he transcription factor NF-κB is an intensively studied
regulator of gene expression involved in immune and inflammatory responses. In most cells,
the bulk of NF-κB is found in the cytoplasm associated with an inhibitor known as IκB. In
response to a variety of stimuli, including the proinflammatory cytokine TNFα, IκB becomes
phosphorylated which leads to its ubiquitination and subsequent degradation by the …
