Activated nuclear factor-κB is present in the coronary vasculature in experimental hypercholesterolemia
SH Wilson, NM Caplice, RD Simari, DR Holmes Jr… - Atherosclerosis, 2000 - Elsevier
Background: Experimental hypercholesterolemia (HC) is characterized by a decrease in
nitric oxide (NO) bioavailability and cellular proliferation. Nuclear factor-κB (NF-κB) is a
transcriptional factor which plays a coordinating role in inflammation and cellular
proliferation and may be involved in early atherosclerosis. We examined whether activated
NF-κB was present in experimental hypercholesterolemia in the coronary vasculature in
association with a decrease in NO bioavailability. Methods: A total of 14 juvenile domestic …
nitric oxide (NO) bioavailability and cellular proliferation. Nuclear factor-κB (NF-κB) is a
transcriptional factor which plays a coordinating role in inflammation and cellular
proliferation and may be involved in early atherosclerosis. We examined whether activated
NF-κB was present in experimental hypercholesterolemia in the coronary vasculature in
association with a decrease in NO bioavailability. Methods: A total of 14 juvenile domestic …
