Shaping the genome–restriction–modification systems as mobile genetic elements
I Kobayashi, A Nobusato… - Current opinion in …, 1999 - Elsevier
I Kobayashi, A Nobusato, N Kobayashi-Takahashi, I Uchiyama
Current opinion in genetics & development, 1999•ElsevierA restriction enzyme gene is often linked to a modification methylase gene the role of which
is to protect a recognition site on DNA from breakage by the former. Loss of some restriction–
modification gene complexes leads to cell death through restriction breakage in the
genome. Their behavior as genomic parasites/symbionts may explain the distribution of
restriction sites and clarify certain aspects of bacterial recombination repair and
mutagenesis. A comparison of bacterial genomes supports the hypothesis that restriction …
is to protect a recognition site on DNA from breakage by the former. Loss of some restriction–
modification gene complexes leads to cell death through restriction breakage in the
genome. Their behavior as genomic parasites/symbionts may explain the distribution of
restriction sites and clarify certain aspects of bacterial recombination repair and
mutagenesis. A comparison of bacterial genomes supports the hypothesis that restriction …
A restriction enzyme gene is often linked to a modification methylase gene the role of which is to protect a recognition site on DNA from breakage by the former. Loss of some restriction–modification gene complexes leads to cell death through restriction breakage in the genome. Their behavior as genomic parasites/symbionts may explain the distribution of restriction sites and clarify certain aspects of bacterial recombination repair and mutagenesis. A comparison of bacterial genomes supports the hypothesis that restriction–modification gene complexes are mobile elements involved in various genome rearrangements and evolution.
Elsevier
