Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum
T Saxne, MA Palladino Jr, D Heinegard… - … : Official Journal of …, 1988 - Wiley Online Library
T Saxne, MA Palladino Jr, D Heinegard, N Talal, FA Wollheim
Arthritis & Rheumatism: Official Journal of the American College …, 1988•Wiley Online LibrarySynovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients
with reactive arthritis contained measurable levels of tumor necrosis factor α (TNFα). Seven
of 12 sera from RA patients contained TNFα, while only 1 of those from reactive arthritis
patients was positive. Gamma‐inter‐feron was detected in the synovial fluids and sera of
only the RA patients. Tumor necrosis factor β was not detected in any sera or synovial fluids.
RA patients with detectable TNFα had higher erythrocyte sedimentation rates and synovial …
with reactive arthritis contained measurable levels of tumor necrosis factor α (TNFα). Seven
of 12 sera from RA patients contained TNFα, while only 1 of those from reactive arthritis
patients was positive. Gamma‐inter‐feron was detected in the synovial fluids and sera of
only the RA patients. Tumor necrosis factor β was not detected in any sera or synovial fluids.
RA patients with detectable TNFα had higher erythrocyte sedimentation rates and synovial …
Abstract
Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor α (TNFα). Seven of 12 sera from RA patients contained TNFα, while only 1 of those from reactive arthritis patients was positive. Gamma‐inter‐feron was detected in the synovial fluids and sera of only the RA patients. Tumor necrosis factor β was not detected in any sera or synovial fluids. RA patients with detectable TNFα had higher erythrocyte sedimentation rates and synovial fluid leukocyte counts.
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