Relation between infection and autoimmunity in mixed cryoglobulinemia
C Ferri, AL Zignego - Current opinion in rheumatology, 2000 - journals.lww.com
Current opinion in rheumatology, 2000•journals.lww.com
Mixed cryoglobulinemia (MC) is a systemic vasculitis of small to medium-sized vessels due
to the vascular deposition of circulating immune-complexes (CIC) and complement. A
leukocytoclastic vasculitis is the histologic hallmark of cutaneous manifestations of the
disease, while a clonal B lymphocyte expansion in blood, bone marrow, liver, and spleen
represents the underlying pathologic alteration responsible for the production of cryo-CIC
and non-cryo CIC with rheumatoid factor activity.
to the vascular deposition of circulating immune-complexes (CIC) and complement. A
leukocytoclastic vasculitis is the histologic hallmark of cutaneous manifestations of the
disease, while a clonal B lymphocyte expansion in blood, bone marrow, liver, and spleen
represents the underlying pathologic alteration responsible for the production of cryo-CIC
and non-cryo CIC with rheumatoid factor activity.
Abstract
Mixed cryoglobulinemia (MC) is a systemic vasculitis of small to medium-sized vessels due to the vascular deposition of circulating immune-complexes (CIC) and complement. A leukocytoclastic vasculitis is the histologic hallmark of cutaneous manifestations of the disease, while a clonal B lymphocyte expansion in blood, bone marrow, liver, and spleen represents the underlying pathologic alteration responsible for the production of cryo-CIC and non-cryo CIC with rheumatoid factor activity.
Lippincott Williams & Wilkins