[HTML][HTML] Transforming growth factor β1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor
JB Hoying, M Yin, R Diebold, I Ormsby, A Becker… - Journal of Biological …, 1999 - ASBMB
Upon activation, platelets store and release large amounts of the peptide transforming
growth factor β1 (TGFβ1). The released TGFβ1 can then act on nearby vascular cells to
mediate subsequent vessel repair. In addition, TGFβ1 may circulate to bone marrow and
regulate megakaryocyte activity. It is not known what effect, if any, TGFβ1 has on platelets.
Adult TGFβ1-deficient mice exhibit thrombocythemia and a mild bleeding disorder that is
shown to result from faulty platelet aggregation. TGFβ1-deficient platelets are shown to …
growth factor β1 (TGFβ1). The released TGFβ1 can then act on nearby vascular cells to
mediate subsequent vessel repair. In addition, TGFβ1 may circulate to bone marrow and
regulate megakaryocyte activity. It is not known what effect, if any, TGFβ1 has on platelets.
Adult TGFβ1-deficient mice exhibit thrombocythemia and a mild bleeding disorder that is
shown to result from faulty platelet aggregation. TGFβ1-deficient platelets are shown to …
