[HTML][HTML] Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens
AD Tepper, SH Diks, WJ van Blitterswijk… - Journal of Biological …, 2000 - ASBMB
Ceramide (Cer) accumulating during the execution phase of apoptosis is generated from
plasma membrane sphingomyelin (SM), which gains access to a sphingomyelinase due to
phospholipid scrambling (Tepper, AD, Ruurs, P., Wiedmer, T., Sims, P., Borst, J., and van
Blitterswijk, WJ (2000) J. Cell. Biol. 150, 155–164). To evaluate the functional significance of
this Cer pool, we aimed to convert it to glucosylceramide (GlcCer), by constitutive
overexpression of glucosylceramide synthase (GCS). Jurkat cells, retrovirally transduced …
plasma membrane sphingomyelin (SM), which gains access to a sphingomyelinase due to
phospholipid scrambling (Tepper, AD, Ruurs, P., Wiedmer, T., Sims, P., Borst, J., and van
Blitterswijk, WJ (2000) J. Cell. Biol. 150, 155–164). To evaluate the functional significance of
this Cer pool, we aimed to convert it to glucosylceramide (GlcCer), by constitutive
overexpression of glucosylceramide synthase (GCS). Jurkat cells, retrovirally transduced …
