Interleukin-15, a leukocyte activator and growth factor, is produced by cortical tubular epithelial cells.
M Weiler, B Rogashev, T Einbinder… - Journal of the …, 1998 - journals.lww.com
Many renal diseases, including transplant rejection, are mediated by mononuclear cells.
Interleukin-15 (IL-15) has been recently described as a cytokine with IL-2-like activity. IL-15
is an effective leukocyte growth factor, activator, and chemoattractant. In rejected human
kidney allografts, elevated IL-15, but not IL-2, mRNA is expressed, suggesting a role for IL-
15 in the rejection process. The aim of this study was to investigate whether human cortical
tubular epithelial cells (HTC) are able to produce IL-15 and whether IL-15 expression is …
Interleukin-15 (IL-15) has been recently described as a cytokine with IL-2-like activity. IL-15
is an effective leukocyte growth factor, activator, and chemoattractant. In rejected human
kidney allografts, elevated IL-15, but not IL-2, mRNA is expressed, suggesting a role for IL-
15 in the rejection process. The aim of this study was to investigate whether human cortical
tubular epithelial cells (HTC) are able to produce IL-15 and whether IL-15 expression is …