CCl4-induced toxicity in isolated hepatocytes: the importance of direct solvent injury
ML Berger, H Bhatt, B Combes, RW Estabrook - Hepatology, 1986 - journals.lww.com
CCl 4 is proposed to induce cellular injury through its metabolites that are generated by a
cytochrome P–450 dependent step. These free radical products can interact with membrane
structures, thereby generating lipid peroxides. The latter process has been implicated as a
major mechanism of CCl 4 hepatoxicity, although this relationship has been difficult to
demonstrate when using isolated hepatocyte preparations. This report demonstrates that
there are at least two mechanisms by which CCl 4 induces injury in isolated hepatocytes …
cytochrome P–450 dependent step. These free radical products can interact with membrane
structures, thereby generating lipid peroxides. The latter process has been implicated as a
major mechanism of CCl 4 hepatoxicity, although this relationship has been difficult to
demonstrate when using isolated hepatocyte preparations. This report demonstrates that
there are at least two mechanisms by which CCl 4 induces injury in isolated hepatocytes …
