Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
S Gengrinovitch, B Berman, G David, L Witte… - Journal of Biological …, 1999 - ASBMB
Glypican-1 is a member of a family of glycosylphosphatidylinositol anchored cell surface
heparan sulfate proteoglycans implicated in the control of cellular growth and differentiation.
The 165-amino acid form of vascular endothelial growth factor (VEGF 165) is a mitogen for
endothelial cells and a potent angiogenic factor in vivo. Heparin binds to VEGF 165 and
enhances its binding to VEGF receptors. However, native HSPGs that bind VEGF 165 and
modulate its receptor binding have not been identified. Among the glypicans, glypican-1 is …
heparan sulfate proteoglycans implicated in the control of cellular growth and differentiation.
The 165-amino acid form of vascular endothelial growth factor (VEGF 165) is a mitogen for
endothelial cells and a potent angiogenic factor in vivo. Heparin binds to VEGF 165 and
enhances its binding to VEGF receptors. However, native HSPGs that bind VEGF 165 and
modulate its receptor binding have not been identified. Among the glypicans, glypican-1 is …
