Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial
SR Steinhubl, PB Berger, JT Mann III, ETA Fry… - Jama, 2002 - jamanetwork.com
ContextFollowing percutaneous coronary intervention (PCI), short-term clopidogrel therapy
in addition to aspirin leads to greater protection from thrombotic complications than aspirin
alone. However, the optimal duration of combination oral antiplatelet therapy is unknown.
Also, although current clinical data suggest a benefit for beginning therapy with a
clopidogrel loading dose prior to PCI, the practical application of this therapy has not been
prospectively studied. ObjectivesTo evaluate the benefit of long-term (12-month) treatment …
in addition to aspirin leads to greater protection from thrombotic complications than aspirin
alone. However, the optimal duration of combination oral antiplatelet therapy is unknown.
Also, although current clinical data suggest a benefit for beginning therapy with a
clopidogrel loading dose prior to PCI, the practical application of this therapy has not been
prospectively studied. ObjectivesTo evaluate the benefit of long-term (12-month) treatment …
