Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway
MT Puglielli, JL Browning, AW Brewer, RD Schreiber… - Nature medicine, 1999 - nature.com
MT Puglielli, JL Browning, AW Brewer, RD Schreiber, WJ Shieh, JD Altman, MBA Oldstone…
Nature medicine, 1999•nature.comAt present, little is known about the pathogenesis of acute virus-induced shock and
pulmonary failure. A chief impediment in understanding the underlying disease mechanisms
and developing treatment strategies has been the lack of a suitable animal model. This
study describes a mouse model of virus-induced systemic shock and respiratory distress,
and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
pulmonary failure. A chief impediment in understanding the underlying disease mechanisms
and developing treatment strategies has been the lack of a suitable animal model. This
study describes a mouse model of virus-induced systemic shock and respiratory distress,
and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
Abstract
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
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