[HTML][HTML] Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-κB translocation
B Opitz, NWJ Schröder, I Spreitzer… - Journal of biological …, 2001 - ASBMB
Recently Toll-like receptors (TLRs) have been found to be involved in cellular activation by
microbial products, including lipopolysaccharide, lipoproteins, and peptidoglycan. Although
for these ligands the specific transmembrane signal transducers TLR-4, TLR-2, or TLR-2
and-6 have now been identified, the molecular basis of recognition of lipoteichoic acids
(LTAs) and related glycolipids has not been completely understood. In order to determine
the role of TLRs in immune cell activation by these stimuli, experiments involving TLR-2 …
microbial products, including lipopolysaccharide, lipoproteins, and peptidoglycan. Although
for these ligands the specific transmembrane signal transducers TLR-4, TLR-2, or TLR-2
and-6 have now been identified, the molecular basis of recognition of lipoteichoic acids
(LTAs) and related glycolipids has not been completely understood. In order to determine
the role of TLRs in immune cell activation by these stimuli, experiments involving TLR-2 …
