Platelet purinergic receptors
SP Kunapuli, RT Dorsam, S Kim, TM Quinton - Current opinion in …, 2003 - Elsevier
Activation of P2Y1 and P2Y12 receptors, through secreted ADP that is stimulated by
agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet
activation. P2X1 receptors also participate in platelet shape change and potentiation of
calcium mobilization. The cloning of the P2Y12 receptor and its subsequent knockout in
mice promises further understanding of its downstream signaling events.
agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet
activation. P2X1 receptors also participate in platelet shape change and potentiation of
calcium mobilization. The cloning of the P2Y12 receptor and its subsequent knockout in
mice promises further understanding of its downstream signaling events.
