[HTML][HTML] Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice
Y Takeuchi, S Watanabe, G Ishii, S Takeda… - Journal of Biological …, 2002 - ASBMB
Cytokines in interleukin (IL)-11 subfamily participate in the regulation of bone cell
proliferation and differentiation. We report here positive effects of IL-11 on osteoblasts and
bone formation. Overexpression of human IL-11 gene in transgenic mice resulted in the
stimulation of bone formation to increase cortical thickness and strength of long bones, and
in the prevention of cortical bone loss with advancing age. Bone resorption and
osteoclastogenesis were not affected in IL-11 transgenic mice. In experiments in vitro, IL-11 …
proliferation and differentiation. We report here positive effects of IL-11 on osteoblasts and
bone formation. Overexpression of human IL-11 gene in transgenic mice resulted in the
stimulation of bone formation to increase cortical thickness and strength of long bones, and
in the prevention of cortical bone loss with advancing age. Bone resorption and
osteoclastogenesis were not affected in IL-11 transgenic mice. In experiments in vitro, IL-11 …