[HTML][HTML] Tumor necrosis factor-α supports the survival of osteoclasts through the activation of Akt and ERK
SE Lee, WJ Chung, HB Kwak, CH Chung… - Journal of Biological …, 2001 - ASBMB
Differentiated osteoclasts have a short life span. We tested various cytokines and growth
factors for the effects on the survival of purified mature osteoclasts. In the absence of any
added factors, osteoclasts exhibited the survival rate of less than 25% after a 24-h
incubation. Among the tested factors, tumor necrosis factor-α (TNF-α) was found to increase
the survival rate to∼ 80%. The TNF-α-enhanced survival of osteoclasts appeared to be
associated with reduction in apoptosis and suppression of caspase activation. The …
factors for the effects on the survival of purified mature osteoclasts. In the absence of any
added factors, osteoclasts exhibited the survival rate of less than 25% after a 24-h
incubation. Among the tested factors, tumor necrosis factor-α (TNF-α) was found to increase
the survival rate to∼ 80%. The TNF-α-enhanced survival of osteoclasts appeared to be
associated with reduction in apoptosis and suppression of caspase activation. The …