Evidence has accumulated that apoptotic cell death contributes to brain damage following
experimental seizures. A substantial number of degenerating neurons within limbic regions
display morphological features of apoptosis following prolonged seizures evoked by
systemic or local injections of kainic acid, systemic injections of pilocarpine and sustained
stimulation of the perforant path. Although longer periods of seizures consistently result in
brain damage, it has previously not been clear whether brief single or intermittent seizures …