Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression
HT Khong, QJ Wang, SA Rosenberg - Journal of immunotherapy, 2004 - journals.lww.com
The authors describe a patient who experienced recurrence of metastatic melanoma after an
initial dramatic response to immunotherapy using peptides derived from gp100, MART-1,
and tyrosinase emulsified in incomplete Freund's adjuvant, and present data to support the
hypothesis that the progression of disease in this patient was due to in vivo immunoselection
for immunoresistant tumor variants. The authors previously demonstrated the existence of T-
cell clones in this patient's peripheral blood and tumor-infiltrating lymphocytes (TILs) reactive …
initial dramatic response to immunotherapy using peptides derived from gp100, MART-1,
and tyrosinase emulsified in incomplete Freund's adjuvant, and present data to support the
hypothesis that the progression of disease in this patient was due to in vivo immunoselection
for immunoresistant tumor variants. The authors previously demonstrated the existence of T-
cell clones in this patient's peripheral blood and tumor-infiltrating lymphocytes (TILs) reactive …