Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
H Mizoguchi, JJ O'Shea, DL Longo, CM Loeffler… - Science, 1992 - science.org
H Mizoguchi, JJ O'Shea, DL Longo, CM Loeffler, DW McVicar, AC Ochoa
Science, 1992•science.orgImpaired immune responses occur frequently in cancer patients or in tumor-bearing mice,
but the mechanisms of the tumor-induced immune defects remain poorly understood. In an
in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26
days develop CD8+ T cells with impaired cytotoxic function, decreased expression of the
tumor necrosis factor-α and granzyme B genes, and decreased ability to mediate an
antitumor response in vivo. T lymphocytes from tumor-bearing mice expressed T cell antigen …
but the mechanisms of the tumor-induced immune defects remain poorly understood. In an
in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26
days develop CD8+ T cells with impaired cytotoxic function, decreased expression of the
tumor necrosis factor-α and granzyme B genes, and decreased ability to mediate an
antitumor response in vivo. T lymphocytes from tumor-bearing mice expressed T cell antigen …
Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26 days develop CD8+ T cells with impaired cytotoxic function, decreased expression of the tumor necrosis factor-α and granzyme B genes, and decreased ability to mediate an antitumor response in vivo. T lymphocytes from tumor-bearing mice expressed T cell antigen receptors that contained low amounts of CD3γ and completely lacked CD3ζ, which was replaced by the Fcε γ-chain. Expression of the tyrosine kinases p56lck and p59fyn was also reduced. These changes could be the basis of immune defects in tumor-bearing hosts.
AAAS