The significance of autoantibodies and immunoglobulins in acute liver failure: a cohort study
W Bernal, Y Ma, HM Smith, B Portmann, J Wendon… - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: The cause of cryptogenic ('seronegative') acute liver failure (ALF) is
unknown; the presence of non-organ specific autoantibodies (NOSA) may indicate an
autoimmune pathogenesis. We investigated the prevalence of autoimmune features
including antibodies to soluble liver antigen (anti-SLA) determined by Radioligand assay
(RLA) in ALF patients. METHODS: The prevalence and relationship to the immunoglobulin
(Ig) response of NOSA and anti-SLA were determined in 73 ALF patients of different causes …
unknown; the presence of non-organ specific autoantibodies (NOSA) may indicate an
autoimmune pathogenesis. We investigated the prevalence of autoimmune features
including antibodies to soluble liver antigen (anti-SLA) determined by Radioligand assay
(RLA) in ALF patients. METHODS: The prevalence and relationship to the immunoglobulin
(Ig) response of NOSA and anti-SLA were determined in 73 ALF patients of different causes …
