Background/Aims: Long-term feeding of mice with a diet containing griseofulvin results in the
formation of Mallory bodies, keratin K8 and K18 containing aggregates in hepatocytes.
These bodies are biochemically and morphologically identical to the Mallory bodies that
emerge in several human liver disorders. The aim of this study was to examine the
contribution of K8 and K18 and actin to Mallory body formation. Methods: Mice were fed
griseofulvin over a period ranging from 1 day to 20 months. Hepatocyte morphology was …