Similar molecular requirements for antigen receptor-triggered secretion of interferon and granule enzymes by cytolytic T lymphocytes
AH Fortier, CA Nacy, MV Sitkovsky - Cellular immunology, 1989 - Elsevier
At least two biologically significant responses are triggered by the crosslinking of the T-cell
receptor (TcR) on the surface of cloned cytotoxic T lymphocytes (CTL): synthesis and
secretion of macrophage-activating factor (s)(MAF) that can be attributed to interferon-γ (IFN)
and release of preformed cytolytic granules. We directly compared the molecular
requirements for synthesis and secretion of IFN and secretion of granule enzymes triggered
in the same cell by the same activating ligand (antigen or monoclonal antibody (mAb) to …
receptor (TcR) on the surface of cloned cytotoxic T lymphocytes (CTL): synthesis and
secretion of macrophage-activating factor (s)(MAF) that can be attributed to interferon-γ (IFN)
and release of preformed cytolytic granules. We directly compared the molecular
requirements for synthesis and secretion of IFN and secretion of granule enzymes triggered
in the same cell by the same activating ligand (antigen or monoclonal antibody (mAb) to …
