Glycogen synthase kinase-3α reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases
P Zhai, S Gao, E Holle, X Yu, A Yatani, T Wagner… - Journal of biological …, 2007 - ASBMB
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase having multiple functions
and consisting of two isoforms, GSK-3α and GSK-3β. Pressure overload increases
expression of GSK-3α but not GSK-3β. Despite our wealth of knowledge about GSK-3β, the
function of GSK-3α in the heart is not well understood. To address this issue, we made
cardiac-specific GSK-3α transgenic mice (Tg). Left ventricular weight and cardiac myocyte
size were significantly smaller in Tg than in non-Tg (NTg) mice, indicating that GSK-3α …
and consisting of two isoforms, GSK-3α and GSK-3β. Pressure overload increases
expression of GSK-3α but not GSK-3β. Despite our wealth of knowledge about GSK-3β, the
function of GSK-3α in the heart is not well understood. To address this issue, we made
cardiac-specific GSK-3α transgenic mice (Tg). Left ventricular weight and cardiac myocyte
size were significantly smaller in Tg than in non-Tg (NTg) mice, indicating that GSK-3α …
