Characterization and role of proteinases induced by estrogen-deprivation in female mouse reproductive tracts
A Suzuki, M Enari, Y Hayashi, Y Ohta… - Reproductive …, 1996 - Elsevier
Normal mouse vaginae and uteri regress following ovariectomy, whereas the vagina of mice
given five daily injections of 3 μg diethylstilbestrol (DES) from the day of birth exhibit ovary
(estrogen)-independent persistent stratification and cornification of the epithelium.
Zymography indicated expression of four proteinases in both vaginae and uteri of normal
mice after ovariectomy. Two proteinases detected in gelatin-containing gel and two others in
casein-containing gel proved to be metalloproteinases and serineproteinases, respectively …
given five daily injections of 3 μg diethylstilbestrol (DES) from the day of birth exhibit ovary
(estrogen)-independent persistent stratification and cornification of the epithelium.
Zymography indicated expression of four proteinases in both vaginae and uteri of normal
mice after ovariectomy. Two proteinases detected in gelatin-containing gel and two others in
casein-containing gel proved to be metalloproteinases and serineproteinases, respectively …
