Allelic imbalance in selected chromosomal regions in ovarian cancer
LL Hansen, LL Jensen, C Dimitrakakis… - Cancer genetics and …, 2002 - Elsevier
Ovarian cancer (OC) is often asymptomatic at the initial stage. When diagnosed, up to 75%
of the patients present grade III or IV tumors with metastasis in nearby organs of the
abdomen. Genetic imbalance is abundant in OC, and allelic loss (AL) of specific
chromosomal regions is considered an early event. To establish association between
genetic markers for early diagnosis/prognosis of OC, our target was to define narrow specific
regions of AL. We analyzed 65 ovarian carcinomas by using 19 microsatellite markers …
of the patients present grade III or IV tumors with metastasis in nearby organs of the
abdomen. Genetic imbalance is abundant in OC, and allelic loss (AL) of specific
chromosomal regions is considered an early event. To establish association between
genetic markers for early diagnosis/prognosis of OC, our target was to define narrow specific
regions of AL. We analyzed 65 ovarian carcinomas by using 19 microsatellite markers …