Coronary heart disease (CHD) is the leading cause of death world-wide. Its major
pathophysiological manifestation is acute myocardial ischaemia–reperfusion injury.
Innovative treatment strategies for protecting the myocardium against the detrimental effects
of this form of injury are required in order to improve clinical outcomes in patients with CHD.
In this regard, harnessing the endogenous protection elicited by the heart's ability to
'condition'itself, has recently emerged as a powerful new strategy for limiting myocardial …