Ischemia reperfusion injury (IRI) is a common and important clinical problem in many
different organ systems, including kidney, brain, heart, liver, lung, and intestine. IRI occurs
during all deceased donor organ transplants. IRI is a highly complex cascade of events that
includes interactions between vascular endothelium, interstitial compartments, circulating
cells, and numerous biochemical entities. It is well established that the innate immune
system, such as complement, neutrophils, cytokines, chemokines, and macrophages …