Tubular epithelial cells transfected with hHGF counteracts monocyte chemotactic protein-1 up-regulation after hypoxia/reoxygenation insult
M Franquesa, M Riera, I Herrero-Fresneda… - Transplantation …, 2009 - Elsevier
Acute kidney injury (AKI) which is mainly produced by nephrotoxic or ischemic insults is
correlated with a high mortality and morbidity. Proximal tubular epithelial cells (PTEC) play a
major role. They are the main target of ischemia/reperfusion injury. PTECs have also been
proposed as the effectors of AKI reversibility, but also as the creator of the inflammatory
milieu: cytokine, chemokine, and complement expression. An important chemokine
implicated in this process is monocyte chemotactic protein-1 (MCP-1) due to its ability to …
correlated with a high mortality and morbidity. Proximal tubular epithelial cells (PTEC) play a
major role. They are the main target of ischemia/reperfusion injury. PTECs have also been
proposed as the effectors of AKI reversibility, but also as the creator of the inflammatory
milieu: cytokine, chemokine, and complement expression. An important chemokine
implicated in this process is monocyte chemotactic protein-1 (MCP-1) due to its ability to …