The Rho kinase pathway plays an important role in dedifferentiation of epithelial cells and
infiltration of inflammatory cells. For testing of the hypothesis that blockade of this cascade
within the kidneys might be beneficial in the treatment of renal injury the Rho kinase
inhibitor, Y27632 was coupled to lysozyme, a low molecular weight protein that is filtered
through the glomerulus and is reabsorbed in proximal tubular cells. Pharmacokinetic studies
with Y27632-lysozyme confirmed that the conjugate rapidly and extensively accumulated in …