The pathobiological mechanisms of emphysema models: what do they have in common?
RM Tuder, S McGrath, E Neptune - Pulmonary pharmacology & …, 2003 - Elsevier
Emphysema results from a multi-step, complex, process of lung destruction. This review
aims at organizing the available information concerning the animal models of emphysema
as to which step o fthe pathogenesis they address. The experimental models have been
classified as to whether they are based on:(a) pharmacological,(b) environmental, or (c)
genetic manipulations to induce emphysema and whether they are:(a) triggers or initiators of
emphysema,(b) modifiers of lung predisposition to further damage by trigger factors, or (c) …
aims at organizing the available information concerning the animal models of emphysema
as to which step o fthe pathogenesis they address. The experimental models have been
classified as to whether they are based on:(a) pharmacological,(b) environmental, or (c)
genetic manipulations to induce emphysema and whether they are:(a) triggers or initiators of
emphysema,(b) modifiers of lung predisposition to further damage by trigger factors, or (c) …
