Administration of nicotinamide during a five-to seven-week course of radiotherapy: pharmacokinetics, tolerance, and compliance
JHAM Kaanders, MRL Stratford, J Liefers… - Radiotherapy and …, 1997 - Elsevier
Background and purpose: Nicotinamide was administered daily as a liquid formulation to
head and neck cancer patients receiving a 5-to 7-week course of radiotherapy. The
pharmacokinetics, compliance, and tolerance of this drug formulation were studied.
Materials and methods: Blood samples were drawn and nicotinamide levels determined in
40 head and neck cancer patients. On the first treatment day serial samples were obtained
followed by daily samples at the time of irradiation during the first and last full weeks of the …
head and neck cancer patients receiving a 5-to 7-week course of radiotherapy. The
pharmacokinetics, compliance, and tolerance of this drug formulation were studied.
Materials and methods: Blood samples were drawn and nicotinamide levels determined in
40 head and neck cancer patients. On the first treatment day serial samples were obtained
followed by daily samples at the time of irradiation during the first and last full weeks of the …