The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity
The androgen receptor (AR) regulates ligand-dependent gene transcription upon binding
specific DNA sequences. The AR conveys both trans-activation and trans-repression
functions, which together contribute to prostate cellular growth, differentiation, and
apoptosis. Like histone H3, the AR is post-translationally modified by both acetylation and
phosphorylation. The histone acetyltransferase p300 transactivates the AR and directly
acetylates the AR in vitro at a conserved motif. Point mutations of the AR acetylation motif …
specific DNA sequences. The AR conveys both trans-activation and trans-repression
functions, which together contribute to prostate cellular growth, differentiation, and
apoptosis. Like histone H3, the AR is post-translationally modified by both acetylation and
phosphorylation. The histone acetyltransferase p300 transactivates the AR and directly
acetylates the AR in vitro at a conserved motif. Point mutations of the AR acetylation motif …
