Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia
H Wang, S Lindsey, I Konieczna, L Bei… - Journal of biological …, 2009 - ASBMB
The homeodomain transcription factor HoxA10 is maximally expressed in myeloid
progenitor cells. Sustained HoxA10 expression during differentiation has been described in
poor prognosis human acute myeloid leukemia (AML). Consistent with this, engineered
overexpression of HoxA10 in murine bone marrow induces a myeloproliferative disorder that
progresses to AML over time. This murine model suggests that HoxA10 overexpression is
sufficient for myeloproliferation but that differentiation block, and therefore AML, requires …
progenitor cells. Sustained HoxA10 expression during differentiation has been described in
poor prognosis human acute myeloid leukemia (AML). Consistent with this, engineered
overexpression of HoxA10 in murine bone marrow induces a myeloproliferative disorder that
progresses to AML over time. This murine model suggests that HoxA10 overexpression is
sufficient for myeloproliferation but that differentiation block, and therefore AML, requires …
