THE EARTH IS SHIFTING BENEATH PSYCHIATRIC GENET-ics. Schizophrenia and other
complex neuropsy-chiatric disorders are characterized by genetic heterogeneity to an extent
far greater than previously recognized. Individually rare mutations, many de novo and others
a few generations old, may be collectively responsible for a substantial portion of mental
illness. The degree of heterogeneity is so great that most unrelated patients may have a
different genetic cause. This phenomenon has fundamental implications for translational …