Reuptake of L-DOPA-derived extracellular dopamine in the striatum with dopaminergic denervation via serotonin transporters
K Kannari, H Shen, A Arai, M Tomiyama, M Baba - Neuroscience letters, 2006 - Elsevier
K Kannari, H Shen, A Arai, M Tomiyama, M Baba
Neuroscience letters, 2006•ElsevierThe aim of our present study was to determine whether exogenous l-DOPA-derived
extracellular dopamine (DA) in the denervated striatum is taken up via serotonin (5-HT)
transporters. Rats with dopaminergic denervation by 6-hydroxydopamine were injected with
l-DOPA 50mg/kg (ip) and extracellular DA levels in the denervated striatum were measured
using in vivo microdialysis technique. During the experiments, fluoxetine, a selective
serotonin reuptake inhibitor, was locally perfused into the striatum through the microdialysis …
extracellular dopamine (DA) in the denervated striatum is taken up via serotonin (5-HT)
transporters. Rats with dopaminergic denervation by 6-hydroxydopamine were injected with
l-DOPA 50mg/kg (ip) and extracellular DA levels in the denervated striatum were measured
using in vivo microdialysis technique. During the experiments, fluoxetine, a selective
serotonin reuptake inhibitor, was locally perfused into the striatum through the microdialysis …
The aim of our present study was to determine whether exogenous l-DOPA-derived extracellular dopamine (DA) in the denervated striatum is taken up via serotonin (5-HT) transporters. Rats with dopaminergic denervation by 6-hydroxydopamine were injected with l-DOPA 50mg/kg (i.p.) and extracellular DA levels in the denervated striatum were measured using in vivo microdialysis technique. During the experiments, fluoxetine, a selective serotonin reuptake inhibitor, was locally perfused into the striatum through the microdialysis probe. Cumulative amounts of l-DOPA-derived extracellular DA during 300min were increased by fluoxetine dose-dependently (10μM and 50μM). These results suggest that reuptake of DA via 5-HT transporters plays an important role in the clearance of l-DOPA-derived DA from the extracellular space when dopaminergic neurons are extensively denervated.
Elsevier
