[HTML][HTML] Long chain CoA esters as competitive antagonists of phosphatidylinositol 4, 5-bisphosphate activation in Kir channels
M Rapedius, M Soom, E Shumilina, D Schulze… - Journal of Biological …, 2005 - ASBMB
Long chain fatty acid esters of coenzyme A (LC-CoA) are potent activators of ATP-sensitive
(K ATP) channels, and elevated levels have been implicated in the pathophysiology of type
2 diabetes. This stimulatory effect is thought to involve a mechanism similar to
phosphatidylinositol 4, 5-bisphosphate (PIP 2), which activates all known inwardly rectifying
potassium (Kir) channels. However, the effect of LC-CoA on other Kir channels has not been
well characterized. In this study, we show that in contrast to their stimulatory effect on K ATP …
(K ATP) channels, and elevated levels have been implicated in the pathophysiology of type
2 diabetes. This stimulatory effect is thought to involve a mechanism similar to
phosphatidylinositol 4, 5-bisphosphate (PIP 2), which activates all known inwardly rectifying
potassium (Kir) channels. However, the effect of LC-CoA on other Kir channels has not been
well characterized. In this study, we show that in contrast to their stimulatory effect on K ATP …