Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment
AM Dworkin, THM Huang, AE Toland - Seminars in cancer biology, 2009 - Elsevier
AM Dworkin, THM Huang, AE Toland
Seminars in cancer biology, 2009•ElsevierEpigenetic alterations of the genome such as DNA promoter methylation and chromatin
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic
modifications as key factors in breast carcinogenesis. These modifications are quite
appealing as targets for preventative care and therapeutics because of their potential for
reversal. Future medical care for breast cancer patients will likely depend upon a better
understanding of the roles epigenetic modifications play in carcinogenesis. Here, we …
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic
modifications as key factors in breast carcinogenesis. These modifications are quite
appealing as targets for preventative care and therapeutics because of their potential for
reversal. Future medical care for breast cancer patients will likely depend upon a better
understanding of the roles epigenetic modifications play in carcinogenesis. Here, we …
Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics because of their potential for reversal. Future medical care for breast cancer patients will likely depend upon a better understanding of the roles epigenetic modifications play in carcinogenesis. Here, we discuss the importance of epigenetics in breast cancer detection, prognosis, and therapy with an emphasis on mechanisms and epigenetic contributions to field cancerization effects.
Elsevier