[HTML][HTML] Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma …
L Riera, E Lasorsa, C Ambrogio, N Surrenti… - Journal of biological …, 2010 - ASBMB
Most anaplastic large cell lymphomas (ALCL) express oncogenic fusion proteins derived
from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK)
gene. Frequently ALCL carry the t (2; 5) translocation, which fuses the ALK gene to the
nucleophosmin (NPM1) gene. The transforming activity mediated by NPM-ALK fusion
induces different pathways that control proliferation and survival of lymphoma cells. Grb2 is
an adaptor protein thought to play an important role in ALK-mediated transformation, but its …
from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK)
gene. Frequently ALCL carry the t (2; 5) translocation, which fuses the ALK gene to the
nucleophosmin (NPM1) gene. The transforming activity mediated by NPM-ALK fusion
induces different pathways that control proliferation and survival of lymphoma cells. Grb2 is
an adaptor protein thought to play an important role in ALK-mediated transformation, but its …