Common variable immune deficiency (CVID) is the commonest symptomatic primary
immunodeficiency and represents a heterogenous collection of disorders resulting mostly in
antibody deficiency and recurrent infections. However, autoimmunity, granulomatous
inflammation and malignancy frequently occur as part of the syndrome. The etiology of the
condition has been poorly understood although in recent years, significant progress has
been made in elucidating genetic mechanisms that can result in a CVID phenotype. In …