Mechanical injury polarizes skin dendritic cells to elicit a TH2 response by inducing cutaneous thymic stromal lymphopoietin expression
MK Oyoshi, RP Larson, SF Ziegler, RS Geha - Journal of allergy and clinical …, 2010 - Elsevier
BACKGROUND: Atopic dermatitis is characterized by scratching and by TH2-dominated
immune response to cutaneously introduced antigens. Antigen application to skin
mechanically injured by tape stripping results in TH2-dominated skin inflammation.
OBJECTIVE: To examine the effect of tape stripping on the capacity of skin dendritic cells
(DCs) to polarize T cells toward a TH2 phenotype. METHODS: CD11c+ DCs were isolated
from skin of BALB/c or C57BL/6 mice. Fluorescein isothiocyanate (FITC)+ and FITC− DCs …
immune response to cutaneously introduced antigens. Antigen application to skin
mechanically injured by tape stripping results in TH2-dominated skin inflammation.
OBJECTIVE: To examine the effect of tape stripping on the capacity of skin dendritic cells
(DCs) to polarize T cells toward a TH2 phenotype. METHODS: CD11c+ DCs were isolated
from skin of BALB/c or C57BL/6 mice. Fluorescein isothiocyanate (FITC)+ and FITC− DCs …
