Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen
MK Oyoshi, GF Murphy, RS Geha - Journal of allergy and clinical …, 2009 - Elsevier
BACKGROUND: Filaggrin is important for skin barrier function and is mutated in 15% to 20%
of patients with atopic dermatitis. OBJECTIVE: To examine whether filaggrin deficiency
predisposes to skin inflammation and epicutaneous sensitization with protein antigen.
METHODS: Skin histology in filaggrin-deficient flaky tail (ft)/ft mice and wild-type controls
was assessed by Hematoxylin and Eosin (H&E) staining and immunohistochemistry.
Cytokine mRNA expression was examined by quantitative RT-PCR. Serum antibody levels …
of patients with atopic dermatitis. OBJECTIVE: To examine whether filaggrin deficiency
predisposes to skin inflammation and epicutaneous sensitization with protein antigen.
METHODS: Skin histology in filaggrin-deficient flaky tail (ft)/ft mice and wild-type controls
was assessed by Hematoxylin and Eosin (H&E) staining and immunohistochemistry.
Cytokine mRNA expression was examined by quantitative RT-PCR. Serum antibody levels …
