Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa
SA Leonard, G Martos, W Wang… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Oral immunotherapy (OIT) is a promising treatment for food allergy. Studies
are needed to elucidate mechanisms of clinical protection and to identify safer and
potentially more efficacious methods for desensitizing patients to food allergens.
OBJECTIVE: We established a mouse model of OIT to determine how the dose or form of
antigen may affect desensitization and to identify mechanisms of desensitization.
METHODS: Increasing doses of egg white or ovomucoid as OIT were administered orally to …
are needed to elucidate mechanisms of clinical protection and to identify safer and
potentially more efficacious methods for desensitizing patients to food allergens.
OBJECTIVE: We established a mouse model of OIT to determine how the dose or form of
antigen may affect desensitization and to identify mechanisms of desensitization.
METHODS: Increasing doses of egg white or ovomucoid as OIT were administered orally to …
