[HTML][HTML] TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria
BA Miller, NE Hoffman, S Merali, XQ Zhang… - Journal of Biological …, 2014 - ASBMB
Cardiac TRPM2 channels were activated by intracellular adenosine diphosphate-ribose and
blocked by flufenamic acid. In adult cardiac myocytes the ratio of G Ca to G Na of TRPM2
channels was 0.56±0.02. To explore the cellular mechanisms by which TRPM2 channels
protect against cardiac ischemia/reperfusion (I/R) injury, we analyzed proteomes from WT
and TRPM2 KO hearts subjected to I/R. The canonical pathways that exhibited the largest
difference between WT-I/R and KO-I/R hearts were mitochondrial dysfunction and the …
blocked by flufenamic acid. In adult cardiac myocytes the ratio of G Ca to G Na of TRPM2
channels was 0.56±0.02. To explore the cellular mechanisms by which TRPM2 channels
protect against cardiac ischemia/reperfusion (I/R) injury, we analyzed proteomes from WT
and TRPM2 KO hearts subjected to I/R. The canonical pathways that exhibited the largest
difference between WT-I/R and KO-I/R hearts were mitochondrial dysfunction and the …