Inflammation contributes to the pathogenesis of acute kidney injury. Dendritic cells (DCs) are
immune sentinels with the ability to induce immunity or tolerance, but whether they mediate
acute kidney injury is unknown. Here, we studied the distribution of DCs within the kidney
and the role of DCs in cisplatin-induced acute kidney injury using a mouse model in which
DCs express both green fluorescence protein and the diphtheria toxin receptor. DCs were
present throughout the tubulointerstitium but not in glomeruli. We used diphtheria toxin to …