CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release
XHT Wehrens - Heart rhythm, 2011 - heartrhythmjournal.com
Contraction of cardiac myocytes is preceded by the influx of Ca2 into the cytosol via voltage-
gated L-type Ca2 channels, which triggers a larger release of Ca2 from the sarcoplasmic
reticulum (SR) through RyR2. 4 The ensuing Ca2 transient leads to myocyte contraction,
which quickly ends when Ca2 is removed from the cytoplasm due to SR Ca2 reuptake
through the SR Ca2-ATPase (SERCA2a) and is extruded via the Na/Ca2-exchanger (NCX).
In healthy hearts, RyR2 remain closed during diastole to facilitate SR refilling before the …
gated L-type Ca2 channels, which triggers a larger release of Ca2 from the sarcoplasmic
reticulum (SR) through RyR2. 4 The ensuing Ca2 transient leads to myocyte contraction,
which quickly ends when Ca2 is removed from the cytoplasm due to SR Ca2 reuptake
through the SR Ca2-ATPase (SERCA2a) and is extruded via the Na/Ca2-exchanger (NCX).
In healthy hearts, RyR2 remain closed during diastole to facilitate SR refilling before the …