Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
C Kellner, M Gramatzki, M Peipp - Oncoimmunology, 2013 - Taylor & Francis
C Kellner, M Gramatzki, M Peipp
Oncoimmunology, 2013•Taylor & FrancisImmunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the
surface of malignant cells by fusing them to antibody fragments. Mimicking an “induced-self”
phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and
synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be
translated into novel immunotherapeutic approaches against cancer.
surface of malignant cells by fusing them to antibody fragments. Mimicking an “induced-self”
phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and
synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be
translated into novel immunotherapeutic approaches against cancer.
Immunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the surface of malignant cells by fusing them to antibody fragments. Mimicking an “induced-self” phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be translated into novel immunotherapeutic approaches against cancer.
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