Mitophagy and Parkinson's disease: be eaten to stay healthy
RLA de Vries, S Przedborski - Molecular and Cellular Neuroscience, 2013 - Elsevier
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders.
Pathologically, it is characterized by the loss of dopaminergic neurons in the substantia
nigra pars compacta (SNc). Although most occurrences have an unknown cause, several
gene mutations have been linked to familial forms of PD. The discovery of some of the
proteins encoded by these genes, including Parkin, PINK1 and DJ-1, at the mitochondria
offered a new perspective on the involvement of mitochondria in PD. Specifically, these …
Pathologically, it is characterized by the loss of dopaminergic neurons in the substantia
nigra pars compacta (SNc). Although most occurrences have an unknown cause, several
gene mutations have been linked to familial forms of PD. The discovery of some of the
proteins encoded by these genes, including Parkin, PINK1 and DJ-1, at the mitochondria
offered a new perspective on the involvement of mitochondria in PD. Specifically, these …