Macrophage phenotype controls long-term AKI outcomes—kidney regeneration versus atrophy
M Lech, R Gröbmayr, M Ryu, G Lorenz… - Journal of the …, 2014 - journals.lww.com
The mechanisms that determine full recovery versus subsequent progressive CKD after AKI
are largely unknown. Because macrophages regulate inflammation as well as epithelial
recovery, we investigated whether macrophage activation influences AKI outcomes. IL-1
receptor–associated kinase-M (IRAK-M) is a macrophage-specific inhibitor of Toll-like
receptor (TLR) and IL-1 receptor signaling that prevents polarization toward a
proinflammatory phenotype. In postischemic kidneys of wild-type mice, IRAK-M expression …
are largely unknown. Because macrophages regulate inflammation as well as epithelial
recovery, we investigated whether macrophage activation influences AKI outcomes. IL-1
receptor–associated kinase-M (IRAK-M) is a macrophage-specific inhibitor of Toll-like
receptor (TLR) and IL-1 receptor signaling that prevents polarization toward a
proinflammatory phenotype. In postischemic kidneys of wild-type mice, IRAK-M expression …